The Ackermann Group
Catalysis And Organic Synthesis

Electrochemistry



Electrosynthesis has emerged as an increasingly viable tool for molecular synthesis with the prospect of avoiding the use of costly and toxic oxidants or reductants, thereby reducing the footprint of undesirable, toxic byproducts. Especially, the merger of C–H functionalization with electrosynthesis significantly improves the atom- and step-economy toward sustainable organic syntheses.

Selected publications:

A) S. Dana,' N. K. Pandit,' P. Boos,' T. von Münchow, S. E. Peters, S. Trienes, L. Haberstock, R. Herbst-Irmer, D. Stalke, L. Ackermann, "Parametrization of κ2-N,O-Oxazoline Preligands for Enantioselective Cobaltaelectro-Catalyzed C–H Activations", ACS Catal. 2025, in press. 'These authors contributed equally Abstract

B) X-Y. Gou,' J. C. A. Oliveira,' S. Chen, S. L. Homölle, S. Trienes, T. von Münchow, B-S. Zhang, L. Ackermann, "Ruthenaelectro-Catalyzed C–H Phosphorylation: ortho to para Position-Selectivity Switch", Chem. Sci. 2025, 16, 824-833. 'These authors contributed equally Abstract

C) M. Hourtoule, S. Trienes, L. Ackermann, "Anodic Commodity Polymer Recycling: The Merger of Iron-Electrocatalysis with Scalable Hydrogen Evolution Reaction", Angew. Chem. Int. Ed. 2024, 63, e202412689. Abstract Press release

D) B-S. Zhang', S. L. Homölle', T. Bauch, J. C. A. Oliveira, S. Warratz, B. Yuan, X-Y. Gou, L. Ackermann, "Electrochemical Skeletal Indole Editing via Nitrogen AtomInsertion by Sustainable Oxygen Reduction Reaction", Angew. Chem. Int. Ed. 2024, 63, e202407384. 'These authors contributed equally Abstract

E) T. von Münchow', S. Dana', Y. Xu, B. Yuan, L. Ackermann, "Enantioselective electrochemical cobalt-catalyzed aryl C–H activation reactions" Science 2023, 379, 1036–1042. 'These authors contributed equally Abstract highlighted on c&en> , Synform