The use of continuous flow methods in C–H activation catalysis is an important process for scaling-up and is particularly suited for for heterogeneous catalysis, with beneficial consequences such as the possibility to reduce the amount of solvent and the increased mechanical stability of the catalyst.
H. Wang,' F. Pesciaioli,' J. C. A. Oliveira, S. Warratz, L. Ackermann, "Synergistic Manganese(I) C–H Activation Catalysis in Continuous Flow: Chemo-Selective Hydroarylation" Angew. Chem. Int. Ed. 2017, 56, 15063–15067.
F. Ferlin, S. Santoro, L. Ackermann, L. Vaccaro, "Heterogeneous C–H Alkenylations in Continuous-Flow: Oxidative Palladium-Catalysis in a Biomass-Derived Reaction Medium" Green Chem. 2017, 19, 2510–2514.