The use of continuous flow methods in C–H activation catalysis is an important process for scaling-up and is particularly suited for for heterogeneous catalysis, with beneficial consequences such as the possibility to reduce the amount of solvent and the increased mechanical stability of the catalyst.

Selected publications:

A) Y. Xu,' Y. Lin,' S. L. Homölle, J. C. A. Oliveira, L. Ackermann, "Enantioselective Cobaltaphotoredox-Catalyzed C–H Activation ", J. Am. Chem. Soc. 2024, 146, 24105-24113. 'These authors contributed equally Abstract

B) Y. Lin, T. von Münchow, L. Ackermann, "Cobaltaelectro-Catalyzed C–H Annulation with Allenes for Atropochiral and P-stereogenic Compounds: Late-stage Diversification and Continuous Flow Scale up"ACS Catal. 2023, 13, 9713-9723. Abstract

C) W.-J. Kong, L. H. Finger, A. M. Messinis, R. Kuniyil, J. C. A. Oliveira, L. Ackermann, "Flow Rhodaelectro-Catalyzed Alkyne Annulations by Versatile C−H Activation: Mechanistic Support for Rhodium(III/IV)" J. Am. Chem. Soc. 2019, 141, 17198-17206. Abstract

D) Y.-F. Liang, R. Steinbock, L. Yang, L. Ackermann, "Continuous Visible Light-Photo-Flow Approach for Manganese-Catalyzed (Het)Arene C−H Arylation" Angew. Chem. Int. Ed. 2018, 57, 10625-10629. Abstract

E) F. Ferlin, L. Luciani, S. Santoro, A. Marrocchi, D. Lanari, A. Bechtoldt, L. Ackermann, L. Vaccaro, "A continuous flow approach for the C–H functionalization of 1,2,3-triazoles in γ-valerolactone as biomass-derived medium" Green Chem. 2018, 20, 2888-2893. Abstract