The Ackermann Group
Catalysis And Organic Synthesis

Ligand Design

The synthesis and use of new ligands in C-H activation catalysis can have a significant impact on reactivities as well as stereo- and regioselectivities. In this context, we have exemplarily disclosed a novel catalyst design based on air- and moisture-stable secondary phosphine oxide (SPO) preligands for efficient C-H arylations of heteroarenes.

Selected publications:

J. Loup, D. Zell, J. C. A. Oliveira, H. Keil, D. Stalke, L. Ackermann, "Asymmetric Iron-Catalyzed C-H Alkylation Enabled by Remote Ligand meta-Substitution" Angew. Chem. Int. Ed. 2017, 56, 14197-14201.

D. Ghorai, V. Müller, H. Keil, D. Stalke, G. Zanoni, B. A. Tkachenko, Peter R. Schreiner, L. Ackermann, "Secondary Phosphine Oxide Preligand for Palladium-Catalyzed C-H (Hetero)Arylations: Efficient Access to Pybox Ligands" Adv. Synth. Catal. 2017, 359, 3137–3141.

L. Ackermann, S. Barfüßer, C. Kornhaaß, A. R. Kapdi, "C–H Bond Arylations and Benzylations on Oxazol(in)es with a Palladium Catalyst of a Secondary Phosphine Oxide" Org. Lett. 2011, 13, 3082–3085.