The Ackermann Group
Catalysis And Organic Synthesis

Peptide Diversification



Methods for the chemoselective modification of amino acids and peptides are powerful techniques in biomolecular chemistry. Non-natural peptides are of key relevance for numerous applied research areas, ranging from proteomics and diagnosis to asymmetric synthesis and drug delivery. In this context, CH activation chemistry is a powerful step- and atom-economical approach for the late-stage modification of peptides.

Selected publications:

M Bauer,' W. Wang,' M. M. Lorion, C. Dong, L. Ackermann, "Internal Peptide Late-Stage Diversification: Peptide Isosteric Triazoles for Primary and Secondary C(sp3)H Activation" Angew. Chem. Int. Ed. 2017, 56, in press.

Z. Ruan,' N. Sauermann,' E. Manoni, L. Ackermann, "Manganese-Catalyzed CH Alkynylation: Expedient Peptide Synthesis and Modification" Angew. Chem. Int. Ed. 2017, 56, 31723176.

A. Schischko, H. Ren, N. Kaplaneris, L. Ackermann, "Bioorthogonal Diversification of Peptides by Selective Ruthenium(II)-Catalyzed CH Activation" Angew. Chem. Int. Ed. 2017, 56, 15761580.