The Ackermann Group
Catalysis And Organic Synthesis

Remote Functionalization



The control of regioselectivty in C–H activations is usually restricted to entropically-favored intramolecular reactions, functionalizations of electronically-biased heteroarenes, or proximity-induced ortho-C–H functionalizations. In sharp contrast, our group has accomplished a wide range of remote C–H functionalizations by ruthenium catalysis.

Selected publications:

J. Li,' K. Korvorapun,' S. De Sarkar,' T. Rogge, D. J. Burns, S. Warratz, L. Ackermann, "Ruthenium(II)-catalysed remote C–H alkylations as a versatile platform to meta-decorated arenes" Nature Commun. 2017, 8, 15430.

S. Warratz, D. J. Burns, C. Zhu, K. Korvorapun, T. Rogge, J. Scholz, C. Jooss, D. Gelman, L. Ackermann, "meta-C–H Bromination on Purine Bases by Heterogeneous Ruthenium Catalysis" Angew. Chem. Int. Ed. 2017, 56, 1557–1560.

J. Li, S. Warratz, D. Zell, S. De Sarkar, E. E. Ishikawa, L. Ackermann, "N-Acyl Amino Acid Ligands for Ruthenium(II)-catalyzed meta-C–H tert-Alkylation with Removable Auxiliaries" J. Am. Chem. Soc. 2015, 137, 13894–13901.

N. Hofmann, L. Ackermann, "meta-Selective C–H Bond Alkylation with Secondary Alkyl Halides" J. Am. Chem. Soc. 2013, 135, 5877–5884.