Integrating a multitask graph neural network with DFT calculations for site-selectivity prediction of arenes and mechanistic knowledge generation X. Chen,^§ Z.-J. Zhang,^§ X. Hong, L. Ackermann,
Nat. Synth 2025, 4, 877-887
Abstract

Difunctionalization of bicyclo[1.1.0]butanes enabled by merging C−C cleavage and ruthenium-catalysed remote C−H activation S. Chen, Z. Xu, B. Yuan, X.-Y. Gou, L. Ackermann
Nat. Synth 2025, 4, 655–663
Abstract

Enantioselective C–H annulations enabled by either nickel- or cobalt-electrocatalysed C–H activation for catalyst-controlled chemodivergence T. von Münchow,^§ N. K. Pandit,^§ S. Dana, P. Boos, S. E. Peters, J. Boucat, Y.-R. Liu, A. Scheremetjew, L. Ackermann
Nat. Catal 2025, 8, 257–269
Abstract

Ruthenaphoto-catalyzed ortho-C–H alkylation with secondary alkyl halides: SET-enabled ruthenium(II/III/IV) manifold Y. Wang,^§ B. Yuan,^§ X. Chang,^§ L. Ackermann
Chem 2025, 11, 102387
Abstract

Machine learning-guided yield optimization for palladaelectro-catalyzed annulation reaction X. Hou, S. Li, J. Frey, X. Hong, L. Ackermann
Chem 2024, 10, 2283-2294
Abstract

Iron-catalyzed stereoselective C–H alkylation for simultaneous construction of C–N axial and C-central chirality Z-J. Zhang, N. Jacob, S. Bhatia, P. Boos, X. Chen, J. C. DeMuth, A. M. Messinis, B. B. Jei, J. C. A. Oliveira, A. Radović, M. L. Neidig, J. Wencel-Delord, L Ackermann
Nat. Commun 2024, 15, 3503
Abstract

Late-stage meta-C–H alkylation of pharmaceuticals to modulate biological properties and expedite molecular optimisation in a single step L. Guillemard, L. Ackermann, M. J. Johansson
Nat. Commun 2024, 15, 3349
Abstract

Stereoselective assembly of C-oligosaccharides via modular difunctionalization of glycals Y-N. Ding, M-Z. Xu, Y-C. Huang, L. Ackermann, X. Kong, X-Y. Liu, Y-Min Liang
Nat. Commun 2024, 15, 2794
Abstract

Room temperature photo-promoted iron-catalysed arene C–H alkenylation without Grignard reagents A. M. Messinis, T. von Münchow, M. Surke, L. Ackermann
Nat. Catal 2024, 7, 273–284
Abstract

Late-stage synthesis of heterobifunctional molecules for PROTAC applications via ruthenium-catalysed C‒H amidation D. Antermite, S. D. Friis, J. R. Johansson, O. D. Putra, L. Ackermann, M. J. Johansson
Nat. Commun 2023, 14, 8222
Abstract

Electrocatalyzed direct arene alkenylations without directing groups for selective late-stage drug diversification Z. Lin,^§ U. Dhawa,^§ X. Hou,^§ M. Surke, B. Yuan, S.-W. Li, Y.-C. Liou, M. J. Johansson, L.-C. Xu, C.-H. Chao, X. Hong, L. Ackermann
Nat. Commun 2023, 14, 4224
Abstract

Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis Z-J. Zhang, S.-W. L, J. C. A. Oliveira, Y. Li, X. Chen, S.-Q. Zhang, L.-C. Xu, T. Rogge, X. Hong, L. Ackermann
Nat. Commun 2023, 14, 3149
Abstract

Enantioselectivity prediction of pallada-electrocatalysed C–H activation using transition state knowledge in machine learning L.-C. Xu, J. Frey, X. Hou, S.-Q. Zhang, Y.-Y. Li, J. C. A. Oliveira, S.-W. Li, L. Ackermann, X. Hong
Nat. Synth 2023, 2, 321–330
Abstract

Enantioselective electrochemical cobalt-catalyzed aryl C–H activation reactions T. von Münchow^§, S. Dana^§, Y. Xu, B. Yuan, L. Ackermann
Science 2023, 379, 1036–1042
Abstract

Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy F. Wang, Y. Chen, W. Rao, L. Ackermann, S.-Y. Wang
Nat. Commun 2022, 13, 2588
Abstract

Rhodaelectro-catalyzed access to chromones via formyl C–H activation towards peptide electro-labeling M. Stangier, A. Messinis, J. C. A. Oliveira, H. Yu, L. Ackermann
Nat. Commun 2021, 12, 4736
Abstract

Late-stage C–H functionalization offers new opportunities in drug discovery L. Guillemard, N. Kaplaneris, L. Ackermann, M. Johansson
Nat. Rev. Chem 2021, 5, 522–545
Abstract

C–H activation T. Rogge, N. Kaplaneris, N. Chatani, J. Kim, S. Chang, B. Punji, L. L. Schafer, D. G. Musaev, J. Wencel-Delord, C. A. Roberts, R. Sarpong, Z. E. Wilson, M. A. Brimble, M. J. Johansson, L. Ackermann
Nat. Rev. Methods Primers 2021, 1, 43
Abstract

Electrocatalytic C–H phosphorylation through nickel(III/IV/II) catalysis S.-K. Zhang, A. Del Vecchio, R. Kuniyil, A. M. Messinis, Z. Lin, L. Ackermann
Chem 2021, 7, 1379-1392
Abstract

Peptide Late-Stage Diversifications by Rhodium-Catalyzed Tryptophan C7 Amidation W. Wang,^§ J. Wu,^§ R. Kuniyil, A. Kopp, R. N. Lima, L. Ackermann
Chem 2020, 6, 3428-3439
Abstract

Power the Future – How Can Electrochemistry Make a Difference in Organic Synthesis? T. H. Meyer, I. Choi, C. Tian, L. Ackermann
Chem 2020, 6, 2484-2496
Abstract

Cobalt-catalysed C–H methylation for late-stage drug diversification S. D. Friis, M. J. Johansson, L. Ackermann
Nat. Chem 2020, 12
Abstract

Cobaltaelectro-Catalyzed C–H Activation for Resource-Economical Molecular Syntheses C. Tian,^§ T. H. Meyer,^§ M. Stangier, U. Dhawa, K. Rauch, L. H. Finger, L. Ackermann
Nat. Protoc. 2020, 15, 1760–1774
Abstract

Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes N. Kaplaneris, J. Son, L. Mendive-Tapia, A. Kopp, N. D. Barth, I. Maksso, M. Vendrell, L. Ackermann
Nat. Commun 2021, 11, 3389
Abstract

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis A. Schischko,^§ N. Kaplaneris,^§ T. Rogge, G. Sirvinskaite, J. Son, L. Ackermann
Nat. Commun 2019, 10, 3553
Abstract

Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides Y. Fang, T. Rogge, L. Ackermann, S.-Y. Wang, S.-J. Ji
Nat. Commun 2018, 9, 2240
Abstract

Versatile and Robust C–C Activation by Chelation-Assisted Manganese-Catalysi H. Wang^§, I. Choi^§, T. Rogge, N. Kaplaneris, L. Ackermann
Nat. Catal 2018, 1, 993-1001
Abstract

Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis P. Gandeepan, L. Ackermann
Chem 2018, 4, 199-222
Abstract

Ruthenium(II)-catalysed remote C-H alkylations as a versatile platform to meta-decorated arenes J. Li,^§ K. Korvorapun,^§ S. De Sarkar,^§ T. Rogge, D. J. Burns, S. Warratz, L. Ackermann
Nat. Commun 2017, 8, 15430
Abstract

Merging allylic carbon-hydrogen and selective carbon-carbon bond activation A. Masarwa, D. Didier, T. Zabrodski, M. Schinkel, L. Ackermann, I. Marek
Nature 2014, 505, 199-203
Abstract